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Gene Editing & Embryology Facility

Utilising cutting edge gene editing technologies

Publications

Total number of publications:

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation.

Green JP, Swanton T, Morris LV, El-Sharkawy LY, Cook J, Yu S, Beswick J, Adamson AD, Humphreys NE, Bryce R, Freeman S, Lawrence C, Brough D

eLife, 2020

doi:10.7554/eLife.59704.

Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease.

Pinteaux E, Abdulaal WH, Mufazalov IA, Humphreys NE, Simonsen-Jackson M, Francis S, Müller W, Waisman A

Journal of molecular medicine (Berlin, Germany), 2020

doi:10.1007/s00109-020-01928-5.

RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of dehydrated hereditary stomatocytosis.

Evans EL, Povstyan OV, De Vecchis D, Macrae FL, Lichtenstein L, Futers TS, Parsonage G, Humphreys NE, Adamson A, Kalli AC, Ludlow MJ, Beech DJ

Blood, 2020

doi:10.1182/blood.2019004174.

Pak2 as a novel therapeutic target for cardioprotective endoplasmic reticulum stress response.

Binder P, Wang S, Radu M, Zi M, Collins L, Khan S, Li Y, Sekeres K, Humphreys NE, Swanton E, Reid A, Pu F, Oceandy D, Guan K, Hille S, Müller OJ, Frey N, Chernoff J, Cartwright EJ, Wang X, Liu W

Circulation research, 2019

doi:10.1161/CIRCRESAHA.118.312829.

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